I faced that formation in the champions league round of 16. Got a 6:1 (0:4) (2:1) aggregate victory with 4-4-2 classic
normal/down the flanks/own half/hard/mixed/zonal. Red arrows on DL, DR, ML and MR. Blue arrows on both MC's.
Also, if possible max player condition, win bonus and try and keep player morale @ superb for all.