I'm currently using 4-1-2-1-2ND and recently I lost against the classic 4-3-3(dmc,aml,amr) and also lost against the 4-3-3(three st). Both teams are weaker than me but they kicked my ass 4-2 and 5-3 in both quarters cup and champions league. I guess those 2 formation can go against 4-1-2-1-2ND. I'm not sure how the 4-3-3(three st) defeated me but I'm pretty sure the 4-3-3 classic defeated me with defensive and attack through both flanks