I don't think I can say more things about 4-5-1.

Focus passing should be mixed in general and you should change it only when you want to counter a specific opponent.
Pressing style, well for 4-5-1 I think own half is ok in general. Use whole pitch when you want to counter some attacking formations that rely on many AMCs/AML/R (eg 4-3-2-1 Christmas tree etc) or when you want to have the most ball possession you can.
Passing style again, mixed unless you go defensive in a game vs a much stronger opponent. Then, you can try long balls.
Marking style I prefer zonal marking all the time in all occasions. I don't like man mark but sometimes (especially when you have many defenders/midfielders and outnumber opponent at your own half) you can go man mark too.