"Against stronger teams it might be better to not use autosubs since you will have a bigger chance to get a good result if one of your players gets injured (the system reacts weird to that)."

I agree with your suggestion, when I'm not able to watch many games I prefer to play a system without DMC and AMC since autosubs replace DMC/AMC's with MC or vice versa (depending which player is on top), you cannot make a differentiation in that.