I've never had a big loss.

In seasons 1, 2 and 3 I did have a lot of big wins.
I think my record is a 12-0 league win.
That changed in season 4, but I still had a few fairly big wins of 5 and 6-0.

Now in season 5, with a reduction in players stats (as always) combined with better opponents who have more experience, I am rotating my squad for cup games and using best players/subs for CL and league.

I'm waiting a few days before clearing out some of my squad, keeping the best young players, clearing out any player below 4 stars and will look to bring in older players with good stats.
I know what I have to buy because I always play the same formation, and prices tend to drop a bit as the season goes on, with older players getting cheaper, and less auction madness.