Maybe the loss was co-incidental, i dont know as i cant remember the exact terms of the injury, but my main gripe was the whole subs thing in general. Given that they offer a Rest Pack for making a sub during the game, they also seem to do their best at denying us the opportunity to earn it.
Subs take so long to come on that if your sub is tactical based, it could work against you, for example if your opponent changes tactic, and you attempt to counter it. Any delay could be crucial. The 'real life' delays should be compensated by your own actual thinking and subs time as the clock runs down. You shouldn't then have to wait up to another ten minutes for a stoppage to enable your player to actually come on.
There are so many of these annoyances to the game that the developers are just short of making the ultimate soccer manager sim.