Using the 4-1-2-1-2 ND as a primary formation, so far I'm having much luck in my league. If I have the better players, I would fight fire with fire if the opponent plays 4-1-2-1-2 as well, and have not lost a match using ND vs ND.

Having that said, if I ever see a 3N-1-4-2 opponent, I would switch to another formation