I think 4-4-2 is a good tactic if you are stronger. Yet, being stronger is not all there is to it. Your players need to be rested, in good mental condition, motivated (wining bonus) etc. Also, if your opponent is on a wining streak, better motivated etc., he still might win.
Specificly, i find that attacking+full pitch pressure is best for my team against weaker teams. I try not changing tactics unless loosing or still 0-0 around 65-70 minute.