At Start of the Saison, I faced this formation (opponent was slighty better). I mostly play 4-5-1V, but their it didn't work. Tactics were defending-long-mixed-on-low-normal-zonal-off.
Was down 0:2 at halftime, switched to 3-3 (MC)-2w-2, hard attacking, high press and won 5:2. But maybe it was big luck.
2nd leg (away) I used 4-2(DMC)-1-2w-1, hard defending-mixed-mixed-on-low-low-zonal-off.
It ends 1:1, but I conceeded the goal from dircet FK, overall he only had 3 shots on target, my team had 8 shots on target.

That's my experience with this formation.