4-3-2-1 no, it's not enough - I said you must use 5D or 4 +1 DMC.
I prefer to give formation advice for defense at a first point.
When oppo is using 4 defenders, what I 'm saying is to use what is working better for you.
If your team working good with AML-AMR-ST go with that
If can play good with 2ST-AMC (ND), go with that.
if the teams are balanced in quality, usually it's the good day/performance of one attacker that 'll judge the result.