I never played vs that formation. I would try: 4-2 (DMC)-1-2 (N or W, depents on your AMx)-1
Hard defending-long-mixed-on-low

But... I manage to win the cup three times a row (this season started with bad luck at Qualifying) and every time, I give an advice, they lose. Things, what work well on my team, often doesn't work on other teams - It was extremly at 1.FA... two members asked me, used my thoughts, lost their games. They tried at 2leg their own way and won...

I think it depends all on your player. You know them, you know, which position is best for them.
F.E. I have an AML/AMC/AMR and he only performs on AMR well.