Flat 3-4-3? Attack him down the wings definitely, and 3-2 in defence has really grown on me lately, DL-DC-DR and two DMCs ahead of them.

What is the difference in quality?

For now, I'll suggest 3-2-2-2-1 as below.

-------ST-------
AML--------AMR-
----MC--MC-----
---DMC--DMC---
DL-----DC----DR

If you don't have the players to do it, still make sure his attacking players are double/triple marked, man-to-man defence and attack him down the wings. Whole pitch pressure and offside traps.