of course it's better from the flanks (vs his 3DC-1DMC), why doubt ?
I would start with
3DC-1DMC-3MC-AML-AMR-ST
or
3DC-1DMC-2MC-AML-AMR-2ST
Thanks Niko, I will try that, anyway I will go in normal mentality and short passes because of his DMC and 5 defenses I supposed he will play defensive and counter.