4-1-4-1
yes

3N-1-4-2,
no, I wouldn't trust only 1DC +1DMC vs 1AMC +2ST

also 4-1-3w-AMC-ST could do some damage

starting with defense/counters in a KO game is a rule for me.
Then decide during the game or in the 2nd leg.
normal, mix, no orders
maybe a blue arrow in a DC and later some red arrows