this is basic analysis before start any match
check all your opposite defenders strength, find out who is weaker defender, is it DL or DR or DC.
if DC is weaker than their DL/DR, use 4-1-2-1-2 and focus through the middle, if side back is weaker use 4-5-1 V start with mixed area
if all their defenders strength is balance, use 4-5-1 V and also start with mixed area,
then during live match, change your passing focus according to the lowest rating opposite defenders.
for example, change your passing focus to right flank if you notice their DL rating is turn lower than 6.5.
you can change from 4-5-1 V to 4-1-2-1-2 if you noticed their DC rating turn low than DL/DR also.
this is basic tactical to take advantage on either weakest player or outperforming player