Please kindly post an image with your team squad like the following, so we could know about your best players and what positions they could play, so we could give the best informed suggestion to you:
https://ibb.co/8bb2FTL
Usually against opponents playing 4 defenders + 2 DMCs, it is best to avoid any play via the middle at all as the chance of being countered is too high.
For a typical match, a 4-5v-1 could do. The 2 in the middle should be 1 MC close to ML/MR region and another is MC close to the other side’s MR/ML region (MC is there just to satisfy the legal formation requirement of having a MC when without both AMC & DMC). Normal/Defensive, mixed/long, via flanks.
And if you only have 1 good AML/R, then it is best to attack only 1 flank and play another MC to control possession instead. Defensive/Hard defending to draw opponents 2 DMCs forward to be intercepted by your 3 MCs instead. Counter on in that case.