I have also notice that even if they can play many positions they do have a favorite position.
But having a wing AML/AMC/AMR on the bench for autosub when you can't watch the game is really nice same with DR/DC/DL. If you don't have that you risk having a sub out of position.
But on defense i normally stick with a DC/DMC autosubber.

I wish we could set up a auto sub for every player on the field. Who in their right mind would throw in a right winger when a left winger get injured and you have a left winger on the bench?