If you absolutely want to HARDCOUNTER a 451v there are a few asymmetric formations that are highly effective.

For common and simple counter I'd say 3-2w-3-0-2(attacking) or 3-0-3-2w-2(defensive) that are specific counter against single DMC.

Most managers don't use DML/DMR pair (hard counter against attacking midfielders) so I don't think you can field the first type.

A vanilla 3-5-2 with both red or both blue arrows on the wing (red arrow with defensive, or blue arrow with aggressive mentality) can also counter it well. Even with no arrows a vanilla 3-5-2 don't have disadvantage against 451v.