You must use 4 defenders to cover oppo attackers (the STs and ML-MR from the flanks).
4-5-1 V isn't working for me vs 4-4-2 classic
so you can try the same (and hope for a better day)
or 4-2-3 (AML-AMC-AMR)- 1
or hex 4-2-2-2
or 4-4-2 nd
there isn't a magic recipe (specially vs this formation) lol