Parshul, the schedule of matches depend on both your time zone and other managers’.
In theory, it could be best if your opponent is living in a +/-12 hours timezone from yours (eg. UK and Aus), so when the game schedule for you to have an early game against someone else could be followed by his/her early game, which would be a late game for you.
The ‘worst’ is to having a similar time zone with both sets of opponents on the same matchday. The game engine has to be fair to try scheduling a game for the convenience (or similarly both a relatively unwelcomed time in the small hours) for both managers. Best is for games to be at least some 9 hours apart, but that cannot be guaranteed as for fairness over a home and away game tie (CL or Cup), there should be an early and late game each for us and the opponent.
Except the final day of a season when a super cup game is always added randomly and ignores the general ‘rule’ of having 3 hours between matches, there should always be a 6% recovery as a minimum. Obviously, dropping from max for some 20% then recovering only 6% will only bring it back to mid-80s. Most likely those players may not perform well for another full 90 minutes, but they should for another 45 minutes. And that’s why we have 17 subs and reserves. Isn’t it?
In real football week (vs a matchday in game), most managers have to sub at least half of regulars, or even 8-9 regulars for a midweek match, and only call on their best player for the last 30 minutes to chase a result if the reserves couldn’t finish the job. That kind of reflects what we need to do in football management (only exception is we want to play our first-11 in every single minute without sub).