Hey Adam, glad you liked it !

Usually, it's always worse to play a player on a wrong position. You'll always get more from him on his natural one, so suggest you avoid that.

Concerning the asymmetric Wingers, you can if you have no other choice. But depending on the formation you're going up against it could be less effective. Using AML/AMR and blue arrows to replace ML/MR, is surely doable, but those AMs won't give you as much midfield control as true Midfielders.
Often, the difference is very slim though, so sure, if you have no other options, go ahead and use them as such !

You might also consider simply playing your AML/AMR at their full strength on that position (meaning with red arrows instead) an orienting your passes on the flanks to attack from there. That can work as well, depending on what you're up against.