Unsymmetrical formation is a little difficult to read the strategy behind.

I'm sorry, I can't give you my best answer on how to beat those formation because I never face it personally. But when I see this, the first strategy come to my mind is the regular 4-1-4-1, short pass, down both flank, counter attack. It's more of a preventive strategy than a counter strategy. Later I'll make a necessary strategy modification during the match based on the statistic and comment, but if the 4-1-4-1 works then I would leave it as it is.

The 4-1-4-1 can change into 3W-1-4-2 or 4-1-3W-2 depends on how the match goes. If I dominate the middle, almost even shot on goal but still no goal for me then I take off 1 MC and put another ST. If the possession is almost even but I have better shot on goal but no goal then I'll take off 1 DC and put another ST.

So my point is, it's about improvisation during the match.