Lost the first Cup game 2:0 at a home game using 3-5-2V vs 4-3N-1-2 (was too tired I overslept <10 minutes towards the start of the match). Opponent was present.
Was lucky the second round. Opponent wasn't online, and out of no-where I had 3 Supporters!! (average being 0 supporters albeit having about 50 TE friends). I used 4-1-4-1 (Attacking, Mixed, Own Half, Hard, Zonal, Mixed Passing) and won his 4-3N-1-2 by 2:0. We went into overtime, and later I manage to dominate him over Penalties.

Conclusion: 4-1-4-1 beats 4-3N-1-2. And support your friend's matches, means a lot to them.