Difference between 5-line defence and 3dc+dml+dmr (defence)

[Javert89]

I have the following doubt:

Against an attacking formation with two wingers it is better, in general, to field a 5-line defence or 3 dc with dml and dmr?

I follow matches but from animations couldn't understand which option work better

So, in general, 5-line defence (assuming you have man)


Or 3dc+dml+dmr?