4-5-1 v

[iptables]

I disagree with the both flanks passing.
Im playing 4-5-1V for 2 seasons now, and never had very hard times vs oppos.
Mentality : If you are Home - start Normal, later, depends on how things are going - Attacking OR Def.
Passing : I start with Mixed, later - Short ( Never used Long ).
Focus : Mixed, later - Mixed.
Counters : On
Pressing : Starting Low, escalation to High, depends on the result and my players' ratings.
Marking : Always used Zonal.
Offside : Depends on your mentality. I start with traps Only if my oppo is stronger than me, otherwise - Off.
Bonusses : Almost all the time - Possesion, later, depends on the result - Attacking. Last 10 mins - Condition.
Note that, you need to have strong wingers for this to work. That means - decent training ( not only stars ).

Edit : About the defenders - DC-DC-DL-DR. Always with 4, no matter what. Keep in mind the DMC here, he plays important role.
DL and DR are almost in the DMC's line and wide. That way, they are acting ALSO as supporting-attacking wingers.
Don't worry, your middle is secured, with the 2 DC's and DMC.