Conventionally, you would choose the first way. It's more balanced as well to have them symmetrically positioned. I only use the middle spot if I have 1 or 3 strikers on the field.
Yeah I use it like that too, it is just that I have seen lots of formations with 2 strikers positioned like the second way
I will try to beat you with 4-1-2-1-2 Narrow Diamond Formation