Earlier i had my first leg of ch l semi final,away,i lost 2-0 to an opponent almost 30% quality lower than me
His formation may cause you troubles.
It's a tough one, specially if have two very good DML-DMR like those.
May give a suggestion -
If you start your game and see that it's not working, maybe try 4-4-2 ND , from the middle
or set 3 DC +1DMC and set an extra AMC to your AML AMR (but mix now, not from the flanks).
Don't be in a hurry and set attack mod.
Stay in def/counter mix pass.
Good luck