I have gotten results with the following tactic against defensive teams.
defensive/flanks/short/off/low/normal/m2m/on
Pulled off a 2-2 and 5-2 against a World Top 100 today with it. Opponent started defense/long pass/counters on/low press.
I changed to defense/flanks/mixed/off/high/normal/m2m/off in 2nd leg. First leg I changed to high press defense + counters and let in the equalizer on the opponents counter-attack.
I understand those tactics look very strange but they have delivered in the past for me against some very good teams.