The biggest difference I noticed is how my players go up and down the flanks, and consequently tried and true tactics started failing. Probably it is just me not using my players correctly. I have been adapting a very new style of play and it has been partially going well and partially... um not so well. But..... I do have a lot of superior opponents in my league that allows me to test a few things, although nothing of great success yet. On the flip side, my Champion's League and Cup have been doing well. It just seems like my team can crush a -5% team but struggles badly against +5% opponent.