Yes, just put your best players on the field in regular not illegal formation. And be sure to avoid some players that keep getting low ratings. Check win bonuses too. that's all
i saw many managers winning trophies playing always the same formation. a guy with 5-1(mc)2w 2 finished fourth in my last league. he had an average q team (the league was made of 13 managers same quality and a bot), his formation was unbalanced, still arrived 4th....
as long as you have a better team you have more chances to win.