The game has some patterns.
For example if you 're playing with wingers or 3 AM (AML-AMC-AMR), your (alone) ST will be a mediocre player.
Even if is +1 star above the wingers.
Only if you put him to take f-k, penalties or ck (to add some assists) will score or get better rates.
Now, if you 're playing 4-4-2 ND, one of the two STs will perform little better than the other.
If you 're playing 4-3-3 flat, one of the three STs will be total crap.
Yes, in those cases maybe hidden characteristics matter.
Don't know cause I don't use 2STs formations (only switching in emergency cases)