I struggle to score against 4-1-2-1-2ND with 4-5-1V.
My team is about 8 points stronger. Out out of 5 games I never won. Did manage a few draws though.
I tried defensive and counter with long passes / whole pitch with short, without counter / or switched my AMR/AML to MR/ML. All of which to no avail.
Possession is about the same, shots on goal too. Every game seems kinda balanced with a slight favour to him.
3N-5-2V was an absolute desaster.
4-1-3W-2 looked a bit better in possession but I played it like 15 minutes of a single game so I don't have statistics on that formation.