I played 2 Cup games against 4-1-3N-2 formation. People were discussing it a lot and I saw about 5 different advises how to beat it, but stayed with 4-3N-2-1. My opponent was 1 level higher and had a little bit better skills on the field.
1st game (at home) my players' conditions were around 50% and the game ended 2:2, he tied it at the very end.
For the 2nd game on the road I rested my players to at least 90% and got pretty easy win. Long passes down both flanks worked perfectly. Both goals came from my AML and I won 2:0.
So I guess 4-3N-2-1 works just fine against 4-1-3N-2.