How to Win Against Any Formation?

[Accyrover]

I'm intending to attack him with 4-3-2-1 with 3 MCs and AML/AMR. I'm at home and I have slightly better quality overall. What do you reckon? How can I stem his DML/DMR?

It depends on the players at your disposal.
It helps when asking for help to post images of both teams, saves time and cuts out the guess work.
ML/MR would stop their advance but obviously the reverse also applies.
Getting someone in between them ties them down if you can keep the defenders busy with ST.
So your formation should work OK.
If you have MR/ML I'd put them on the bench just in case you need to change the point of attack by going three wide, then your AMC cover his MC's when you lose possession.