Depending on the players position availability, the ‘easiest’ is 4-5v-1.

If opponent ST is too strong for even 2 DCs, then can consider 3-3-2M-1W-1. Basically 3 DCs vs 1ST, DL + DMC + DR man-marking 3 AMs, 2 MCs pulled wide to control Mc area plus wide midfield areas, and 1 winger + 1 ST. If AM is too strong, then can try 4-2DM-2-1W-1.

Key is to avoid central area with opponent DMC, and make use of deployed fullbacks plus midfielders to add to winger to overload a flank to win.