Thats Why i try to keep my team balanced between first 11 and subs, i only use reds in last case. I now have medical facilitys to maximum, 1 red from gifts each day( thanks Saransh) and lukily from games played, not so often.
I do this in all my team and in all i have above 200.
If i have to play a player out of position i do it. The fun thing is that sometimes my subs play better that my first option for the position.