Every 2-3 seasons (if I don't train my players) I sell them all on the last day of season and buy 10-14 new scout players .. however, first few games go terribly wrong .. (against teams that are 10-15q lower) .. it usually takes about 5 games till they play well together (you have to adjust the places as well) ST MC DC, some ST/MC/DC perform better on right rather than left etc, etc, .. left foot striker usually play on right side, right side striker play on left .. I hope you get the point .. so I believe the answer is YES.

Good luck.