Well, this system, 4-5-1 V it's one of the 4-5 most popular formations. You can play with orders defensive/through flanks/counter and it's maybe the most successful formation against better q teams.
Also I can add that for unknown reasons, many times, it's favoured by the program
I play against it with 3 Def. wide, 1 DMC to cut the oppo counters, 2 MC, 2 wingers and 2 ST.
With that positions you can face all oppo counters, specially if you have better quality and in good form players.
But the key is to play with the same defending mentality and counters. If you try attack it can destroy you.
If you are unlucky and take a goal from the oppo, things are very tough cause as you trying attacking, the more dangerous is to accept a second goal from counters.
So be patient