Lets think that every league have a different scenario, so by default, as game want you to manage, the game select some matches, maybe 1-2 teams of the table that for some reason have a favourable scenario.

Thats a reason to change the wholse strategy? no.
Thats a reason to try to manage the situation for the only way that can be managed, that is inside the same match.
If one see that fail continously, are the sub's and changes of orders in this particular match what can help one to overcome the situation.
We all have this team, or 2, maybe 3, that for some reason are capable to face us, and believe me, chaneg the whole system for one team, is not the way.
Because the game was made to make managers manage. And manage is not spend via Visa, for a whole 6* team. Pu the team and thats all, nope.
Manage is manage, know your team, test, have a way to play, and prepare 2nd strategies for the case/scenario that you say.