You have to see which are your best essencial players and what tactics you can use with your squad. Out of the blue without knowing your team I would say you need at least 3in the middle (MC-MC-MC) or MR-MC-ML or put down arrows in your AM's. For one ST you should only need 3 D's but I personally prefer the classic 4defensive line. We can always see the MR and ML very active in this kind of squads.