I have never had any problems with 4-4-2 with the formation I use for Al FC:
Click image for larger version.  Name: Al taktik.jpg  Views: 49  Size: 68.8 KB  ID: 71238

Normal/mixed/mixed/off/low and so forth.

You don't face that many 4-4-2 teams that are that good, but I faced a good opponent in the last association game:
Click image for larger version.  Name: Motståndare FA.jpg  Views: 48  Size: 41.8 KB  ID: 71239
Click image for larger version.  Name: FA motstånd taktik.jpg  Views: 48  Size: 71.9 KB  ID: 71240

The first game was fairly close but I still won pretty comfortable.
Click image for larger version.  Name: FA match 1.jpg  Views: 48  Size: 90.6 KB  ID: 71241

In the second game I got him good at home, 5-0 before he got a red card and I could win 8-0 in total.
Click image for larger version.  Name: FA match 2.jpg  Views: 48  Size: 94.6 KB  ID: 71242

What you get is basically a 3 on 2 situation at center midfield and you get a 3 on 2 against the strikers (and three DCs in general, which always is good against all players), in turn you give up a 2 on 1 on your right side and only have one ST against 2 DCs. But a good DMR can handle a DL and ML very good, its nothing that will kill you. One striker against two DCs is also no big problem. So I will definitely take those odds against a 4-4-2 any day, getting an advantage at MC and having three DCs you are just hard to beat.