That's when you suspect that the game is "rigged" and you will end up losing it, despite how much effort you put into making subs, tactical or formation changes. I've been in the same situation 3x times!
It's nothing you can do about, just try to treat the game as a "game" and nothing else. Otherwise you will just end up tired, frustrated, and at the end just GIVE UP on it all.
Anyway, at least you gave it a try and will recieve a 3rd place trophy as a "thanks" for your devotion & dedication for making it so far.