thru my experience this season i use that formation to beat 451v. i beat that formation against oppo slightly higher then me with 41212 attack thru middle.
sometime is the player v player you have to look at not just team quality. you try to exploit your oppo weakness study their defence look at the player rating in game and before.
look at their defence skill see if you have attack that can match or better them. you have option in attack left/right or centre. etc if you play 451v and notice that their dr is weak you can exploit then switch to attack from left move your amr to centre to put more pressure(doesnt matter if he dont hv that sp) you can still use him. sometime you need to take risk and be brave.