4-1-2-1 with up arrows on the DMC and AMC smashes 4-5-1 no arrows.
This dominates possesion in the midfield and gives the CBs too much to handle. The only job your full backs will have is collecting the ball out of the back of the net.
The managers in the latter stages of CL (who know how to play) are taking advantage of those who get their football strategy from a online forum. I know this because I come up against them all time!