Well, those would be the main concerns, but you actually get about as many skill points, just that they are spread out among more players. In some cases, this would actually bring you a higher profit if you were to sell on the players.

Also, you say the players will lose morale much faster, but I have no problems with them. Everybody I need is on deep green right now, only my 2* youth and a midfielder whom I haven't used for a while are on orange morale. I'm not using the midfielder because he is quite old and already on 84 quality, I would rather get my other midfielders up to 84 because they seem to sell better if they are close to the next star level.