Almost all the time I play 4-5-1V with short passing, so far my team is doing very good.
Once I've asked Niko for a speciffic draw ( team with 30% above me ) with a flat 4-4-2. Niko adviced me to try mixed, and if AM say smth bad - change to short.
That's what I did. No matter I lost 2:1, the short passing really did great job.
Test for yourself I'd say, and see where is the weak spot in your setup