I usually find where my players play the best and keep them there. I've had left-footed MCs play on the right and vice-versa. The ones you can't do anything with are the left -sided players (DL/DML/ML/AML) that are right-footed and right-side players that prefer their left foot...

I suppose my classic example is the Palace Casuals right-winger (screen shot taken when I finally decided to put him out for sale...

Click image for larger version.  Name: PC Johan Shaqiri Stats Final HL.jpg  Views: 94  Size: 92.1 KB  ID: 83665

...not many goals, but over 90 assists...