As I said, my MR and ML both can play MC (and they play MC in my default 451v). In that 4-3-3 I put them really close to MC box, almost on the border, so they gave possession on flanks and in the center. I had three my midfielders in the gaps between his midfielders. I don't think going through the middle would change things drastically.
I don't remember exactly about my AMR and AML, but I think I left them in the middle of their boxes.
The opponents were watching the games, and we changed formations in the 2nd half. I rarely, if not never, play the same formation for the whole match against equal teams.